Baby powder is a substance used for diaper changes with infants.
Mainstream Smurfs Media[]
In mainstream Smurfs media, baby powder is often used on Baby Smurf.
Empath Stories[]
In the EMPATH: The Luckiest Smurf story series, it is also used on Psycheliana and the children of Empath's fellow Smurfs.
Hero Stories[]
Presumably it was used on Saviour and Miracle and the children of Hero's fellow Smurfs in the HERO: The Guardian Smurf story series, as it was also used on Angelo in the Glovey Smurf story series.